Mmm Camments
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چکیده
Number 51 Recently, President Reagan signed a bill to reduce federal spending over the next three years by $130 billion. Almost as soon as the ink dried, Administration officials announced that further reductions totaling about $75 billion were needed to erase the federal budget deficit by 1984. Subsequently, it became evident that even that was not enough. It is clear that these budget plans will adversely affect many research and development (R&D) programs that depend on federal support. In the past, I've expressed concern about support for scientific research. l-s As early as 1973, I discussed the need for a lobby to advance the interests of research scientists. 1 More recently, I concentrated on how we might prove the value of basic researches These issues are even more compelling today, in view of the planned reductions in R&D funding. In this essay, I'll try to report in detail on the estimated impact of R&D on the American economy—its contributions to the US gross national product (GNP) and industrial productivity. Unfortunately , it is a vital subject for which there are only limited, but still important , data available. R&D is an umbrella term covering three separate activities-basic research , applied research, and development. The National Science Foundation (NSF) defines basic research as " knowledge or understan&lng of the fundamental aspects of phenomena and observable facts without specific ap-December 21,1981 placations.. .in mind. ' " rApplied research determines " the means by which a recognized and specific need may be met,' " 1 according to NSF. Finafly, NSF says development is concerned with the " production of useful materials, devices, systems, or methods, including design and development of prototypes and processes.' " f Table 1 shows the federal obligations to R&D at NSF and the National Institutes of Health (NIH) for fiscal years 1979-1982. The government's 1980 fiscal year (FY), for example, started on Oc-tober 1, 1979, and ended on September 30, 1980. The data in Table 1 represent the total amounts committed for orders, contracts, and services by NSF and NIH. They take into account the cutbacks and amendments proposed by the Office of Management and Budget (OMB) for FY 1981. However, they do not reflect Congress' later decision to restore the funds earmarked for elimination from NIH's 1981 budget. Also, the figures reported for 1982 should be read as " lower liiit " amounts, since the budget for that …
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Progress in Nondestructive Evaluation of Stress Concentration with MMM Method
It has been proved by experiments that the metal magnetic memory (MMM) NDT method can effectively detect the stress concentration of ferromagnetic metal parts. But it is still hard to evaluate the stress concentration quantitatively because of the confusion in the mechanism of MMM method. In this paper experiments are designed and carried out to investigate the relationship between the MMM sign...
متن کاملMMM: a sequence-to-structure alignment protocol
MOTIVATION Accurate alignment of a target sequence to a template structure continues to be a bottleneck in producing good quality comparative protein structure models. RESULTS Multiple Mapping Method (MMM) is a comparative protein structure modeling server with an emphasis on a novel alignment optimization protocol. MMM takes inputs from five profile-to-profile based alignment methods. The al...
متن کاملImproved model-order reduction by using spacial information in moments
The new concept of multinode moment matching (MMM) is introduced in this paper. The MMM technique simultaneously matches the moments at several nodes of a circuit using explicit moment matching around = 0. As compared to the well known single-point moment matching (SMM) techniques (such as asymptotic waveform evaluation), MMM has several advantages. First, the number of moments required by MMM ...
متن کاملCirculating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia.
PURPOSE Endothelial progenitor cells (EPCs) are present in circulation and contribute to vasculogenesis in adults. We measured the number of circulating EPCs in patients with myelofibrosis with myeloid metaplasia (MMM), and we examined the relationship between the number of EPCs and severity of the MMM disease process. PATIENTS AND METHODS The number of EPCs was measured by assaying the CD34+...
متن کاملX-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis.
The JAK2V617F mutation is present in most patients with polycythemia vera (PV) and in some patients with essential thrombocythemia (ET) and myeloid metaplasia/myelofibrosis (MMM). We sought to investigate the relationship between granulocyte clonality and JAK2V617F allelic ratio. A total of 168 of 190 female patients were informative for a clonality assay at the HUMARA locus; 80% of MMM, 75% of...
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